Involvement of Human Papillomavirus Infections in Prostate Cancer Progression – Abstract

June 27, 2008 – 6:57 pm

I found this article last month and have let it sit for a bit.  While this blog may at first appear to be off-topic, it’s not…my friend was diagnosed with cervical cancer from HPV infection from her husband.  She was told that there is no way to test a man for the HPV virus.  The only way to know that there is HPV is if the woman  has an abnormal PAP smear, etc.

I found it hard to believe that a virus exists that can be transmitted from one human to another could not be tested.  I still find it hard to believe and this is where I bring this back to topic…maybe now that there is evidence of HPV in prostate cancer, there might be a way to use this information to create some diagnostic formula/test via the prostate…any cancer prevented is great news no matter who benefits.

I’d like to see more research dollars go into cross-analyzing male and female reproductive diseases and disorders, as there has to be a connection somewhere between one and the other…

Friday, 16 May 2008

Written by
Al Moustafa AE.

Segal Cancer Center, Lady Davis Institute for Medical Research of the Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.

Program in Cancer Genetics, Department of Oncology, McGill University, Montreal, Quebec, Canada.

High-risk human papillomaviruses (HPVs) are sexually transmitted and have been associated with several human carcinomas especially cervical and colorectal. On the other hand, a small number of studies have examined the presence of high-risk HPV in human prostate cancer tissues. Currently, the presence and role of high-risk HPV infections in prostate carcinogenesis remain unclear because of the limited number of investigations. This raises the question whether high-risk HPV infections play any role in human prostate cancer development. However, other investigators and our group were able to immortalize normal and cancer prostate epithelial cells in vitro by E6/E7 of HPV type 16. In this paper, we propose the hypothesis that normal and cancer prostate epithelial cells are susceptible to persistent HPV infections; therefore, high-risk HPV infections play an important role in the progression of prostate cancer. We believe that an international collaboration of epidemiological studies and more molecular biology investigations are necessary to answer these important questions.

Med Hypotheses. 2008 May 9. Epub ahead of print.

At any rate, any bonafide research that can further determine causes of diseases will most certainly benefit humans the world over.

Best to you,


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